Camel milk is widely used for its reported anti-diabetic and health promoting effects. Lipids derived from the milk have also been shown to exhibit potent anti-inflammatory effects. The mechanism through which these lipids and constituent fatty acids exert these effects remains elusive.

This paper demonstrates the ability of camel milk lipids to regulate gBSA-induced macrophage inflammation in vitro, by modulating the expression of key inflammatory regulators such NF-kB and NLRP3 inflammasome subunit.

“Results: Gas Chromatography-Mass Spectrometry (GC-MS) analysis found that TL was 96% triacylglycerol (TAG) while the TFA comprised 65% saturated and 35% unsaturated fatty acids. Both TL and TFA significantly (p<0.05) decreased gBSA-induced secretion of pro-inflammatory cytokines (Tumour necrosis factor-(TNF)-α, Interleukin-(IL)-1β/18). TL also demonstrated the ability to regulate the expression of p50/p65 sub-units of Nuclear Factor-kappa B (NF-κB), while concomitantly increasing the expression of regulatory cytokines IL-10, IL-1 Receptor Antagonist (IL-1Ra) and Cluster of Differentiation 163 (CD163)-shifting cells towards an M2 macrophage phenotype. Additionally, we found that TL significantly regulated the expression of Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome subunit and its regulator; Ten-Eleven Translocation-2 (TET-2).”

For detail, please go to the link below.

• https://mastopedia.wordpress.com/2019/05/27/lipids-derived-from-camel-milk-regulate-nlrp3-inflammasome-dependent-inflammatory-responses-in-human-macrophages/
• http://theconversation.com/camel-milk-reduces-cell-inflammation-associated-with-type-2-diabetes-117031
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389616/
• https://www.dromacity.org/découvrir-le-dromadaire/un-produit-phare-le-lait-de-chamelle/
• https://camel4milk.wordpress.com/2019/04/15/camel-milk-works-as-anti-inflammatory/